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KMID : 0366220100450010070
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Korean Journal of Hematology
2010 Volume.45 No. 1 p.70 ~ p.72
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A case of donor-derived granulocytic sarcoma after allogeneic hematopoietic stem cell transplantation
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Jeong Seong-Hyun
Kang Seok-Yun
Lee Hyun-Woo
Choi Jin-Hyuk
Park Joon-Seong
Han Jae-Ho
Jeong Seon-Yong
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Abstract
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The occurrence of granulocytic sarcoma as a pattern of relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is rare. In this paper, we report a rare case of acute myeloid leukemia (AML) relapsed as a granulocytic sarcoma of the donor type. The patient was diagnosed as having AML and underwent an allo-HSCT from his matched sibling donor. Fifty-seven months after allo-HSCT, he developed granulocytic sarcomas of duodenum, jejunum, and left sterno-cleido-mastoid muscle. The bone marrow was normal with 100% donor chimerism. A Y chromosome PCR was performed on the patient’s duodenum specimen as well as bone marrow aspirate in order to check the patient-origin cells. The duodenal specimen was found to contain 41.2% SRY-positive cells (from the donor). Repeat endoscopy on day 2 of chemotherapy showed that the granulocytic sarcoma had shrunk dramatically. The patient died of sepsis during the nadir state 35 days after starting salvage chemotherapy.
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KEYWORD
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Granulocytic sarcoma, AML, Allo-HSCT, Donor type
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